Vit A deficiency
Vit A is a fat soluble vitamin,it exerts important functions in the body:
- Formation of the visual pigment.
- Maintenance of epithelial surface integrity.
- Formation of mucopolysaccharides in the matrix of bones and teeth.
- Essential for growth.
Sources of vitamin A
- Animal fat,milk and milk products,egg yolk,liver, especially cod liver.
- Yellow and green fruits and vegetables like carrots 🥕.
Daily requirements
4000 IU vit A per day.
Causes of vit A deficiency
- Deficient intake(vegetarian diet).
- Impaired absorption, celiac disease,cholestatic jaundice.
- Deficient storage as in liver cirrhosis.
- Hyporoteinemiaas in kwashiorkor.
Manifestation of vit A deficiency
Eye manifestation:
- Night blindness
- Xerophthalmia (dryness of conjunctiva).
- Keratomalacia(softness of cornea).
- Corneal ulceration
- Bitot spots (dry white plaques on the bulbar conjunctiva).
Skin and mucous membranes:
- Xerosis of skin.
- Follicular hyperkeratosis over the buttocks.
- Recurrent respiratory and urinary infections.
Skeletal system
For the normal children, we give two doses, the first will be 100,000 IU orally at age of 9 . months,the second will be 200,000 IU orally at 18 months.
For high risk children :
- For infants < 6 months :single oral dose 50,000IU.
- For infants 6:12months : single oral dose 100,000IU.
- For infants> 12 months : single oral dose 20,000IU.
Treatment
- For infants < 6 months :single oral dose 50,000IU.
- For infants 6:12months : single oral dose 100,000IU.
- For infants> 12 months : single oral dose 20,000IU.
Alternatively we can give oral Vit A 5000 to 10,000 IU /day for 2 weeks.
And in malabsorption, raise the dose to 10,000 to 25,000 IU/day for 2 weeks.
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