Today we are talking about Turner’s syndrome.
the most common karyotype is 45XO with the second X is missing.
Clinical picture:
- Short stature less than 150cm
- sexual infantilism due to ovarian dysgenesis:amenorrhea.
- webbed neck,low hair line,widely separated hypoplastic nipples.
- cubitus valgus of elbows
- congenital anomalies like coarcitation of the aorta
Treatment:
1-parentral GH for the short stature initiated in early childhood.
2-around the age of 12 years old start low dose oral estrogen for 6-12months and then followed by cyclic therapy to induce menses.
we do that due to the gonadal dysgenesis,so it is a hypergonadoropic hypogonadism.
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